Thermo Fisher Scientific POLK Polyclonal Antibody

Product Specifications

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant Human POLK if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:POLK,uniProtId:Q9UBT6-1,ncbiNodeId:9606,antigenRange:151-283,antigenLength:870,antigenImageFileName:PA5-64942_POLK_Q9UBT6-1_Rabbit.svg,antigenImageFileNamePDP:PA5-64942_POLK_Q9UBT6-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.3 mg/mL

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2665056

Product Specific Information

Immunogen sequence: AMPGFIAKRLC PQLIIVPPNF DKYRAVSKEV KEILADYDPN FMAMSLDEAY LNITKHLEER QNWPEDKRRY FIKMGSSVEN DNPGKEVNKL SEHERSISPL LFEESPSDVQ PPGDPFQVNF EEQNNPQILQ NS

Highest antigen sequence identity to the following orthologs - mouse 82%, rat 80%.

Target Information

External and internal DNA-damaging agents continually threaten the integrity of genetic material in cells. Although a variety of repair mechanisms exist to remove the resulting lesions, some lesions escape repair and block the replication machinery. Members of the Y family of DNA polymerases, such as POLK, permit the continuity of the replication fork by allowing replication through such DNA lesions. Each Y family polymerase has a unique DNA-damage bypass and fidelity profile. POLK is specialized for the extension step of lesion bypass.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.