Thermo Fisher Scientific NO66 Polyclonal Antibody
Thermo Fisher Scientific의 NO66 Polyclonal Antibody는 인간, 마우스, 랫트 시료에 반응하는 Rabbit IgG 항체입니다. IHC(P) 실험에 적합하며, NO66 단백질의 메틸화 조절 연구에 활용됩니다. 액상 형태로 제공되며, -20°C에서 보관합니다.
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:30–1:150
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthesized peptide derived from human NO66 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.4, with 40% glycerol |
| Contains | 0.05% sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2688542 |
Product Specific Information
Predicted to react with Mouse and Rat samples.
Target Information
Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Specifically demethylates Lys-4 (H3K4me) and Lys-36 (H3K36me) of histone H3, thereby playing a central role in histone code regulation. Preferentially demethylates trimethylated H3 Lys-4 (H3K4me3) and monomethylated H3 Lys-4 (H3K4me1), with weaker activity for dimethylated H3 Lys-36 (H3K36me2). Also catalyzes hydroxylation of 60S ribosomal protein L8 on His-216. Acts as a regulator of osteoblast differentiation via interaction with SP7/OSX by demethylating H3K4me and H3K36me, thereby inhibiting SP7/OSX-mediated promoter activation. May play a role in ribosome biogenesis and heterochromatin remodeling, and participates in MYC-induced transcriptional activation. [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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