Thermo Fisher Scientific MPP5/Pals1 Polyclonal Antibody
Rabbit polyclonal antibody targeting human MPP5/Pals1, validated for WB and IP applications. Recognizes residues 600–650 of MPP5. Predicted cross-reactivity with mouse and orangutan. Supplied as liquid, 1 mg/mL, stored at 4°C. For research use only.
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000–1:10,000
Immunoprecipitation (IP)
- Tested Dilution: 2–10 µg/mg lysate
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 600–650 of human MAGUK p55 subfamily member 5 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- Based on 100% sequence identity, predicted to react with Mouse and Orangutan
Target Information
MPP5 (Membrane Protein, Palmitoylated 5) plays a critical role in neurogenesis and hematopoiesis. It is essential for establishing and maintaining cell polarity in epithelial cells and neurons. MPP5 participates in the Par-3 complex, which supports tight junctions in epithelial cells. Mutations in MPP5 are linked to severe neurologic impairments such as global developmental delay (GDD) and behavioral abnormalities. In animal models, MPP5 contributes to early differentiation of multipotent progenitors and supports long-term lineage-specific development, particularly in myeloid and lymphoid cells. Variants of MPP5 disrupt normal cellular function, causing developmental and functional defects.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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