Thermo Fisher Scientific RNF20 Polyclonal Antibody
RNF20 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. 인간 시료에 반응하며 ICC/IF에 사용 가능. 액상 형태로 4°C 또는 -20°C 보관. Affinity chromatography로 정제된 고품질 연구용 시약.
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Thermo Fisher Scientific RNF20 Polyclonal Antibody
Applications
- Immunocytochemistry (ICC/IF): 0.25–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant Protein Epitope Signature Tag (PrEST) antigen sequence (Antigen range: 78–211). Recombinant protein control fragment: Product #RP-109730 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.05 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_3092174 |
Product Specific Information
Immunogen sequence:
KLERRQATDD ASLLIVNRYW SQFDENIRII LKRYDLEQGL GDLLTERKAL VVPEPEPDSD SNQERKDDRE RGEGQEPAFS FLATLASSSS EEMESQLQER VESSRRAVSQ IVTVYDKLQE KVELLSRKLN SGDN
Antigen sequence identity:
- Mouse: 98%
- Rat: 99%
Target Information
RNF20 is an E3 ubiquitin ligase that regulates chromosome structure by monoubiquitinating histone H2B. It selectively suppresses the expression of proto-oncogenes and growth-related genes by interfering with the chromatin recruitment of transcription elongation factor SII (TFIIS).
Conversely, RNF20 positively regulates the p53 tumor suppressor and numerous histone H2A and H2B genes. Together with USP44, RNF20 modulates stem cell differentiation through H2B monoubiquitination.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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