Thermo Fisher Scientific SOCS3 Monoclonal Antibody (1B2)
SOCS3 단백질을 표적으로 하는 Thermo Fisher Scientific의 단클론 항체(1B2). Western blot, ICC/IF, ELISA에 사용 가능하며 인간 및 생쥐 시료에 반응. Protein A로 정제된 액상 항체로, PBS(pH 7.4)에 0.1% sodium azide 포함. 연구용 전용 제품.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | Assay-dependent | View 3 publications |
| Immunocytochemistry (ICC/IF) | - | View 1 publication |
| ELISA | Assay-dependent | View publications |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Published Species | Human, Mouse |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 1B2 |
| Immunogen | Synthetic peptide derived from the N-terminal region of the mouse SOCS-3 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.1% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2533337 |
Target Information
Cytokine receptor signaling is negatively regulated by the SOCS (Suppressor of Cytokine Signaling) family, which includes eight members: SOCS-1, 2, 3, 4, 5, 6, 7, and CIS. SOCS proteins contain an N-terminal region of variable length, a central SH2 domain, and a C-terminal SOCS box. These proteins function as part of a classical negative feedback loop that modulates cytokine signal transduction through a STAT-induced transcriptional mechanism. Transcription of SOCS genes occurs rapidly in response to cytokines, and each member inhibits signaling in distinct ways.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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