Thermo Fisher Scientific CYP11A1 Polyclonal Antibody, MaxPab

Applications

• Western Blot (WB): 1:500–1:1,000

Product Specifications

Product Specific Information

Protein sequence:
MLAKGLPPRS VLVKGCQTFL SAPREGLGRL RVPTGEGAGI STRSPRPFNE IPSPGDNGWL NLYHFWRETG THKVHLHHVQ NFQKYGPIYR EKLGNVESVY VIDPEDVALL FKSEGPNPER FLIPPWVAYH QYYQRPIGVL LKKSAAWKKD RVALNQEVMA PEATKNFLPL LDAVSRDFVS VLHRRIKKAG SGNYSGDISD DLFRFAFESI TNVIFGERQG MLEEVVNPEA QRFIDAIYQM FHTSVPMLNL PPDLFRLFRT KTWKDHVAAW DVIFSKADIY TQNFYWELRQ KGSVHHDYRG ILYRLLGDSK MSFEDIKANV TEMLAGGVDT TSMTLQWHLY EMARNLKVQD MLRAEVLAAR HQAQGDMATM LQLVPLLKAS IKETLRLHPI SVTLQRYLVN DLVLRDYMIP AKTLVQVAIY ALGREPTFFF DPENFDPTRW LSKDKNITYF RNLGFGWGVR QCLGRRIAEL EMTIFLINML ENFRVEIQHL SDVGTTFNLI LMPEKPISFT FWPFNQEATQ Q

Target Information

CYP11A1, also known as cytochrome P450C11A1, cytochrome P450scc, and cytochrome P450 subfamily XIA, is an enzyme that catalyzes the first step of steroid biosynthesis under the modulation of the cAMP signal.
In steroidogenic cells, CYP11A1 converts cholesterol to pregnenolone, regulated by hormonal control of cholesterol availability.
Expression of the CYP11A1 gene is controlled by the transcription factor SF-1, with the upstream SF-1 binding site required for hormonal stimulation.
c-Jun and SF-1 may act synergistically to activate CYP11A1 gene expression. Both Forskolin and 8-Br-cAMPS elevate CYP11A1 mRNA levels in interstitial cell monolayers with functional adenylate cyclase.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.