Thermo Fisher Scientific C19orf10 Polyclonal Antibody
Human C19orf10 단백질을 인식하는 Rabbit Polyclonal Antibody로 Western blot 및 IHC(P) 검증 완료. 항원 친화 크로마토그래피로 정제되었으며, PBS 기반 용액 형태로 제공. 연구용으로 알레르기 반응 및 면역 조절 연구에 적합.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:500–1:1,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human C19orf10. Recombinant protein control fragment (Product # RP-98885) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2638856 |
Product Specific Information
Immunogen sequence:
YLYFTQFKAE VRGAEIEYAM AYSKAAFERE SDVPLKTEEF EVTKTAVAHR PGAFKAELSK LVIVAKASRT EL
Highest antigen sequence identity to orthologs:
- Mouse: 93%
- Rat: 89%
Target Information
Interleukins are a broad family of cytokines primarily derived from hematopoietic cells. These small soluble proteins regulate immune system functions and mediate inflammatory responses.
IL-25 (also known as SF20/IL-25) is a secreted bone marrow stroma-derived growth factor cytokine from Th2 T-cells. It belongs to the IL-17 cytokine family and amplifies allergic-type inflammatory responses by acting on other cell types.
IL-25 binds to mouse thymic shared antigen-1 and supports lymphoid cell proliferation. Infusion of IL-25 induces IL-4, IL-5, and IL-13 gene expression, leading to epithelial cell hyperplasia, mucus secretion, and airway hyperreactivity.
This suggests IL-25 may play a key role in allergic disease through induction of IL-4, IL-5, IL-13, and eotaxin.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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