Thermo Fisher Scientific GSTM4 Polyclonal Antibody

Applications

Tested Application and Dilution

• Immunohistochemistry (Paraffin) (IHC (P)): 1:100–1:200

Product Specifications

Product Specific Information

This antibody detects endogenous levels of total GSTM4 protein.

Target Information

Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. Eight distinct classes of soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta, and zeta.
This gene encodes a glutathione S-transferase belonging to the mu class. The mu class of enzymes functions in detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins, and oxidative stress products, by conjugation with glutathione.
Genes encoding the mu class enzymes are located in a cluster on chromosome 1p13.3 and are highly polymorphic, affecting susceptibility to toxins and drug response. Multiple transcript variants encoding distinct isoforms have been identified.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.