Thermo Fisher Scientific HnRNP Q Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

Antibody detects endogenous levels of total hnRNP Q.

Target Information

Heterogenous nuclear ribonucleoprotein (hnRNP) implicated in mRNA processing mechanisms. Component of the CRD-mediated complex that promotes MYC mRNA stability. Isoform 1, isoform 2, and isoform 3 are associated in vitro with pre-mRNA, splicing intermediates, and mature mRNA protein complexes. Isoform 1 binds to apoB mRNA AU-rich sequences and is part of the APOB mRNA editosome complex, possibly modulating posttranscriptional C to U RNA-editing of APOB mRNA by interacting with A1CF, APOBEC1, or RNA. It may be involved in translationally coupled mRNA turnover and in cytoplasmic mRNA decay mechanisms. Isoform 3 may participate in cytoplasmic vesicle-based mRNA transport via interaction with synaptotagmins. It is also a component of the GAIT (gamma interferon-activated inhibitor of translation) complex, mediating interferon-gamma-induced, transcript-selective translation inhibition during inflammation. Upon interferon-gamma activation, it assembles into the GAIT complex, binding to GAIT elements in 3′-UTRs of inflammatory mRNAs (e.g., ceruloplasmin) to suppress translation; though not essential for GAIT complex function.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.