Thermo Fisher Scientific VPS72 Polyclonal Antibody

Thermo Fisher Scientific VPS72 Polyclonal Antibody

Applications

• Western Blot (WB): Tested dilution 0.06 µg/mL

Product Specifications

Product Specific Information

• Immunogen sequence: TEELNLRSLE TYERLEADKK KQVHKKRKCP GPIITYHSVT VPLVGEPGPK
• Storage guidance: For short term use, store at 2–8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
• Predicted homology:
  Cow: 100%
  Dog: 100%
  Guinea Pig: 100%
  Horse: 100%
  Human: 100%
  Mouse: 100%
  Rabbit: 100%
  Rat: 100%
  Zebrafish: 92%

Target Information

Vacuolar protein sorting-associated protein 72 homolog (VPS72), also known as VPS72 or Transcription factor-like 1, is a 364 amino acid subunit of the TRRAP/TIP60 HAT complex. VPS72 has also been identified as a subunit of a novel complex containing SNF2-related helicase SRCAP (SWI2/SNF2-related CBP activator protein). This SRCAP-containing complex is very similar to the S. cerevisiae SWR1 chromatin remodeling complex.
The involvement of VPS72 in these complexes suggests that VPS72 plays multiple roles in chromatin modification and remodeling in cells. VPS72 localizes to the nucleus and is phosphorylated upon DNA damage, most likely by ATM or ATR.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.