Thermo Fisher Scientific Collagen I Polyclonal Antibody

Applications

Immunohistochemistry (Frozen) (IHC (F))

• Tested Dilution: 1:10–1:20

ELISA

• Tested Dilution: Assay-dependent

Product Specifications

Product Specific Information

Reconstitute with 1 mL of distilled water and add preservative if preferred.

Target Information

Collagen I is a Type I collagen with a triple helix structure comprised of two alpha-1 chains and one alpha-2 chain. It is a fibril-forming collagen found in most connective tissues and is abundant in bone, cornea, dermis, and tendon.
Mutations in the COL1A2 gene encoding the alpha-2 chain are associated with osteogenesis imperfecta (types I–IV), Ehlers-Danlos syndrome type VIIB, recessive Ehlers-Danlos classical type, idiopathic osteoporosis, and atypical Marfan syndrome.
Symptoms from COL1A2 mutations tend to be less severe than those from COL1A1 mutations, reflecting the different roles of alpha-2 chains in matrix integrity.
Reciprocal translocations between chromosomes 17 and 22, where Collagen Type I genes and the gene for platelet-derived growth factor beta are located, are associated with dermatofibrosarcoma protuberans, a skin tumor resulting from unregulated growth factor expression.
Two transcripts resulting from alternate polyadenylation signals have been identified.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.