Thermo Fisher Scientific Phospho-ASK1 (Ser966) Polyclonal Antibody
Human ASK1 (phospho Ser966)을 인식하는 Rabbit Polyclonal Antibody로, Western blot에 적합. 항원 친화 크로마토그래피로 정제되었으며 PBS/BSA/glycerol buffer에 보존. 세포 스트레스 반응 및 MAPK 신호 연구에 유용.
- 판매단위
- pk
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Applications
Tested Application
- Western Blot (WB): 1:500–1:3,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Carrier-protein conjugated synthetic peptide corresponding to residues around human ASK1 (phospho Ser966). The exact sequence is proprietary. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.3 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7, with 1% BSA, 20% glycerol |
| Contains | 0.025% ProClin 300 |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2902031 |
Product Specific Information
- Centrifuge briefly prior to opening.
Target Information
MAP3K5 (ASK1) is a serine/threonine kinase abundantly expressed in human heart and pancreas. It is activated by various extracellular stimuli such as cytokines, growth factors, and environmental stresses.
ASK1 (Apoptosis Signal-Regulating Kinase 1), also known as MAPKKK5, activates MKK4 and MKK6, which in turn activate JNK and p38 MAP kinases.
ASK1 is activated by TNFR and Fas through interactions with TRAF family members and Daxx. Overexpression induces apoptosis, while inactive forms inhibit TNF-α-induced apoptosis. ASK1 is expressed in a variety of human and mouse tissues.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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