Thermo Fisher Scientific TIS11D Polyclonal Antibody

Applications

Immunohistochemistry (IHC)

• Tested Dilution: 1:50–1:200
• Publications: --

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: —
• Publications: --

Product Specifications

Product Specific Information

Immunogen sequence:
MSTTLLSAFY DVDFLCKTEK SLANLNLNNM LDKKAVGTPV AAAPSSGFAP GFLRRHSASN LHALAHPAPS PGSCSPKF

Ortholog sequence identity:

• Mouse: 94%
• Rat: 94%

Target Information

TIS11D, also known as ZFP36LA (zinc finger protein 36, C3H type-like 2), BRF2 (butyrate response factor 2), ERF2, or RNF162C, is a 494 amino acid protein that localizes to the nucleus and contains two CSH1-type zinc fingers.
Belonging to the TIS11 family of early response proteins, TIS11D is thought to function as a nuclear transcription factor that binds to 5UUAUUUAUUU-3 core RNA sequences and may regulate growth factor-induced cellular responses.
The gene encoding TIS11D maps to human chromosome 2, which houses over 1,400 genes and comprises nearly 8% of the human genome.
Harlequin ichthyosis, a rare and severe skin deformity, is associated with mutations in the ABCA12 gene, while the lipid metabolic disorder sitosterolemia is associated with defects in the ABCG5 and ABCG8 genes.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.