Thermo Fisher Scientific KLC1 Polyclonal Antibody
Thermo Fisher Scientific의 KLC1 Polyclonal Antibody는 인간 KLC1 단백질을 인식하는 토끼 IgG 항체입니다. Western blot과 IHC(P)에서 검증되었으며, 높은 종간 유사성을 가진 항원에 특이적입니다. 항원 친화 크로마토그래피로 정제되어 연구용으로 적합합니다.
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Thermo Fisher Scientific KLC1 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:500 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human KLC1. Recombinant protein control fragment (Product #RP-97608). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2643127 |
Product Specific Information
Immunogen sequence:
STMVYIKEDK LEKLTQDEII SKTKQVIQGL EALKNEHNSI LQSLLETLKC LKKDDESNLV EEKSNMIRKS LEMLE
Highest antigen sequence identity to orthologs:
- Mouse: 97%
- Rat: 96%
Target Information
Conventional kinesin is a tetrameric molecule composed of two heavy chains and two light chains, and transports various cargos along microtubules toward their plus ends. The heavy chains provide the motor activity, while the light chains bind to various cargos.
This gene encodes a member of the kinesin light chain family. It associates with kinesin heavy chain through an N-terminal domain, and six tetratricopeptide repeat (TPR) motifs are thought to be involved in binding of cargos such as vesicles, mitochondria, and the Golgi complex.
Thus, kinesin light chains function as adapter molecules and not motors per se. Although previously named kinesin 2, this gene is not a member of the kinesin-2 / kinesin heavy chain subfamily of kinesin motor proteins.
Extensive alternative splicing produces isoforms with different C-termini that are proposed to bind to different cargos; however, the full-length nature of some of these variants has not been determined.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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