Thermo Fisher Scientific INSR Polyclonal Antibody

Applications and Tested Dilution

• Application: Immunohistochemistry (Paraffin) (IHC (P))
• Tested Dilution: 20–40 µg/mL

Product Specifications

Product Specific Information

• In IHC applications, antigen retrieval using a citrate buffer (pH 6.0) is recommended.
• Percent identity with other species by BLAST analysis:
  • Human, Monkey: 100%
  • Bovine, Horse: 89%
  • Mouse, Rat, Dog, Panda: 83%

Target Information

INSR (Insulin Receptor) is a receptor tyrosine kinase that mediates insulin signaling. Binding of insulin to the extracellular domain of INSR stimulates glucose uptake. INSR and IGF-1 receptors share major structural and functional similarities. The earliest cellular response to insulin stimulation is autophosphorylation of tyrosine residues in INSR.
In humans, the INSR gene is located on chromosome 19. Defects in INSR are associated with various insulin resistance syndromes, while IGF-1R defects may lead to certain forms of growth retardation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.