Thermo Fisher Scientific INSR Polyclonal Antibody
Rabbit polyclonal antibody targeting human Insulin Receptor (INSR). Validated for IHC (paraffin) with recommended dilution 20–40 µg/mL. High specificity confirmed by BLAST analysis. Suitable for detecting insulin signaling pathways in human and primate...
- 카탈로그번호
- PA532877
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific INSR Polyclonal Antibody
Applications and Tested Dilution
- Application: Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 20–40 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Non-human primate |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic 18 amino acid peptide from internal region of human Insulin Receptor |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.1% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2550338 |
Product Specific Information
- In IHC applications, antigen retrieval using a citrate buffer (pH 6.0) is recommended.
- Percent identity with other species by BLAST analysis:
- Human, Monkey: 100%
- Bovine, Horse: 89%
- Mouse, Rat, Dog, Panda: 83%
Target Information
INSR (Insulin Receptor) is a receptor tyrosine kinase that mediates insulin signaling. Binding of insulin to the extracellular domain of INSR stimulates glucose uptake. INSR and IGF-1 receptors share major structural and functional similarities. The earliest cellular response to insulin stimulation is autophosphorylation of tyrosine residues in INSR.
In humans, the INSR gene is located on chromosome 19. Defects in INSR are associated with various insulin resistance syndromes, while IGF-1R defects may lead to certain forms of growth retardation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.