Thermo Fisher Scientific Dysadherin Polyclonal Antibody
Human Dysadherin 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal 항체로, Western blot, IHC(P), ICC/IF에 적합합니다. 항원 친화 크로마토그래피로 정제되었으며, PBS/glycerol buffer에 보관됩니다. 암 연구 및 세포 부착 관련 연구에 유용합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:20–1:50 | - |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human Dysadherin (Product # RP-90023) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C (short term). For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2640854 |
Product Specific Information
Immunogen sequence:
DTTSSSSADS TIMDIQVPTR APDAVYTELQ PTSPTPTWPA DETPQPQTQT QQLEGTDGPL VTDPETHKST KAAHPTDDTT TLSERPSPST DVQTDPQTLK PSGFHEDDPF FYDEHTLR
Antigen sequence identity (orthologs):
- Mouse: 33%
- Rat: 31%
Target Information
This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing several conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator.
- Mouse FXYD5 has been termed RIC (Related to Ion Channel).
- FXYD2 (gamma subunit of Na,K-ATPase) regulates enzyme properties.
- FXYD1 (phospholemman), FXYD2 (gamma), FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) can induce channel activity in expression systems.
- Transmembrane topology established for FXYD1 and FXYD2: N-terminus extracellular, C-terminus cytoplasmic.
- FXYD5 (Dysadherin) is a glycoprotein that upregulates chemokine production and reduces cell adhesion by downregulating E-cadherin.
- It promotes metastasis and is linked to various cancers.
- Alternative splicing results in multiple transcript variants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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