Thermo Fisher Scientific PFKFB3 Polyclonal Antibody
PFKFB3 단백질을 인식하는 Rabbit Polyclonal 항체로 Western blot 및 Immunocytochemistry에 적합. Human 시료 반응성. 항원 친화성 크로마토그래피로 정제되었으며, PBS/glycerol buffer에 보관. 세포 주기 및 대사 연구용으로 적합.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human PFKFB3. Recombinant protein control fragment (Product # RP-89865) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.10 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2856154 |
Product Specific Information
Immunogen sequence:
EEAMKVRKQC ALAALRDVKS YLAKEGGQIA VFDATNTTRE RRHMILHFAK ENDFKAFFIE SVCDDPTVVA SNIMEVKISS PDYKDCNSAE AMDDFMKRIS CYEASYQPLD PDKCDRDLSL IKVIDVGRRF LVNRVQD
Target Information
The protein encoded by this gene belongs to a family of bifunctional proteins involved in both the synthesis and degradation of fructose-2,6-bisphosphate, a key regulator of glycolysis in eukaryotes.
It exhibits both 6-phosphofructo-2-kinase and fructose-2,6-biphosphatase activities, controlling F2,6BP levels.
This protein is essential for cell cycle progression and prevention of apoptosis, acting as a regulator of cyclin-dependent kinase 1 and linking glucose metabolism to cell proliferation and survival in tumor cells.
Multiple alternatively spliced transcript variants encoding different isoforms have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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