Thermo Fisher Scientific Phospho-Chk1 (Ser280) Recombinant Rabbit Monoclonal Antibody (6Y6I4)
인간 CHK1 단백질의 Ser280 인산화 부위를 인식하는 재조합 토끼 단클론 항체. Western blot 및 ELISA에 적합하며 높은 특이성과 재현성을 제공. Protein A 정제, 액상 형태, 연구용으로만 사용 가능.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:1,000
ELISA
- Tested Dilution: 1 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 6Y6I4 |
| Immunogen | A synthetic phosphorylated peptide around S280 of human Chk1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.21 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol, 0.05% BSA |
| Contains | 0.05% ProClin 300 |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
Product Specific Information
- Immunogen Sequence: VTSGG
Target Information
CHEK1 (CHK1) is a serine/threonine protein kinase involved in preventing replication when DNA integrity is compromised. CHK1 is a key mediator in the DNA damage-induced checkpoint network and functions to ensure genomic integrity upon genotoxic stress. Inhibition of CHK1 can lead to mitotic catastrophe in p53-deficient cancer cells, making CHK1 an attractive therapeutic target for cancer treatment.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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