Thermo Fisher Scientific GGCX Polyclonal Antibody
Thermo Fisher Scientific의 GGCX Polyclonal Antibody는 인간, 마우스, 랫트 시료에서 GGCX 단백질을 검출하는 고품질 항체입니다. Western Blot 및 Immunocytochemistry에 적합하며, 합성 펩타이드 유래 항원으로 제작되었습니다. 액상 형태로 안정적이며 연구용으로 사용됩니다.
- 카탈로그번호
- PA5100252
- 판매단위
- pk
카탈로그
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:100–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human GGCX (Accession P38435), corresponding to amino acid residues A365–Y415 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2815782 |
Product Specific Information
Antibody detects endogenous levels of total GGCX.
Target Information
GGCX (gamma-glutamyl carboxylase), also known as GC or VKCFD1 (Vitamin K-dependent gamma-carboxylase), is a 758 amino acid multi-pass membrane protein localized to the endoplasmic reticulum membrane.
It mediates vitamin K-dependent carboxylation of glutamate residues on target proteins, producing calcium-binding gamma-carboxyglutamate (Gla) residues and converting vitamin K to vitamin K epoxide.
GGCX exists as a monomer and modifies glutamate residues to enable activity of vitamin K-dependent proteins such as blood coagulation and bone matrix proteins.
Defects in the GGCX gene cause combined deficiency of vitamin K-dependent clotting factors 1 (VKCFD1) and PXE-like disorder with multiple coagulation factor deficiency, characterized by abnormal skin, blood, or bone function.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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