Thermo Fisher Scientific GP1BA Monoclonal Antibody (1C6)
Thermo Fisher Scientific의 GP1BA Monoclonal Antibody (1C6)는 인간 CD42b 단백질을 인식하는 Mouse IgG2a 항체입니다. Western blot, ELISA, Immunoprecipitation에 적합하며, 액상 형태로 제공됩니다. VEGF 및 PDGF 관련 혈소판 활성화 연구에 유용합니다.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–5 µg/mL |
| ELISA | 0.03 ng/mL |
| Immunoprecipitation (IP) | 1–5 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host/Isotype | Mouse / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 1C6 |
| Immunogen | GP1BA (AAH27955, 19 a.a. approximately 128 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
ICEVSKVASH LEVNCDKRNL TALPPDLPKD TTILHLSENL LYTFSLATLM PYTRLTQLNL DRCELTKLQV DGTLPVLGTL DLSHNQLQSL PLLGQTLPAL TVLDVPFNRL
Target Information
CD42b is a platelet activation marker involved in coagulation as an aggregating factor. It interacts with extracellular matrix and adhesion molecules. CD42b expression and activation are regulated by VEGF and PDGF. It forms the GPIb-IX-V receptor complex, crucial for platelet-rich thrombus formation. CD42b binds von Willebrand factor (VWF), thrombin, coagulation factors XI and XII, high molecular weight kininogen, TSP-1, integrin Mac-1, and P-selectin. The extracellular domain contributes to metastasis. CD42b antigen is expressed on platelets and megakaryocytes. Mutations in CD42b are associated with Bernard-Soulier syndrome and platelet-type von Willebrand disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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