Thermo Fisher Scientific JAK1 Recombinant Rabbit Monoclonal Antibody (23GB2245)

Applications

Western Blot (WB)

• Tested Dilution: 1:1,000–1:5,000

Immunocytochemistry (ICC/IF)

• Tested Dilution: 1:1,000

Product Specifications

Target Information

Janus kinase 1 (JAK1) is a protein tyrosine kinase involved in interferon-α/β and -γ signal transduction pathways. Immunological stimuli, such as interferons and cytokines, induce recruitment of Stat transcription factors to cytokine receptor-associated JAK1. JAK1 phosphorylates proximal Stat factors, which subsequently dimerize, translocate to the nucleus, and bind to cis elements upstream of target gene promoters to regulate transcription. Upon ligand binding, JAK1 undergoes tyrosine phosphorylation and catalytic activation in an interdependent manner. Phosphorylation of tyrosine residues at positions 1022 and 1023 is believed to play a role in activation of catalytic events.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.