Thermo Fisher Scientific JAK1 Recombinant Rabbit Monoclonal Antibody (23GB2245)
JAK1 단백질을 표적으로 하는 Thermo Fisher의 재조합 토끼 단클론 항체. Western blot 및 면역세포염색에 적합하며, HEK293F 시스템에서 발현된 고순도 항체. 인간, 생쥐, 랫트 반응성. 연구용으로만 사용 가능.
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000–1:5,000
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293F |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 23GB2245 |
| Immunogen | A synthesized peptide derived from human JAK1 (625–660AA) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice (domestic); Dry ice (international) |
Target Information
Janus kinase 1 (JAK1) is a protein tyrosine kinase involved in interferon-α/β and -γ signal transduction pathways. Immunological stimuli, such as interferons and cytokines, induce recruitment of Stat transcription factors to cytokine receptor-associated JAK1. JAK1 phosphorylates proximal Stat factors, which subsequently dimerize, translocate to the nucleus, and bind to cis elements upstream of target gene promoters to regulate transcription. Upon ligand binding, JAK1 undergoes tyrosine phosphorylation and catalytic activation in an interdependent manner. Phosphorylation of tyrosine residues at positions 1022 and 1023 is believed to play a role in activation of catalytic events.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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