Thermo Fisher Scientific SUPT6H Polyclonal Antibody
SUPT6H 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal 항체. Western blot, IHC, IP 등 다양한 응용에 사용 가능. 항원 친화 크로마토그래피로 정제되었으며, 4°C에서 보관. 전사 연장 및 mRNA 처리 연구에 적합.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000–1:10,000 |
| Immunohistochemistry (IHC) | 1:200–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:500 |
| Immunoprecipitation (IP) | 2–5 µg/mg lysate |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 425 and 475 of Human Suppressor of Ty 6 Homolog (SPT6) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.20 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | TBS, pH 7.0–8.0, with 0.1% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt.
- For IHC, epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.
Target Information
SUPT6H (Suppressor of Ty 6 Homolog) is a transcription elongation factor that binds histone H3 and plays a key role in regulating transcription elongation and mRNA processing. It enhances RNA polymerase II (RNAPII) elongation and is essential for activation by the HIV-1 Tat protein.
SUPT6H forms a complex with IWS1 and the CTD of RNAPII subunit RPB1 (POLR2A), recruiting mRNA export factors (ALYREF/THOC4, EXOSC10) and histone-modifying enzymes (e.g., SETD2) to ensure proper mRNA splicing, export, and elongation-coupled H3K36 methylation.
Through association with SETD1A, it regulates class-switch recombination and somatic hypermutation by forming H3K4me3 marks on AICDA loci, and promotes myogenic gene activation by facilitating H3K27me3 demethylation via KDM6A stabilization.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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