Thermo Fisher Scientific p53 FL-393 Polyclonal Antibody
다양한 응용 분야(WB, IHC, ICC, Flow, ELISA)에 사용 가능한 p53 FL-393 폴리클로날 항체. 인간, 마우스, 랫트 반응성. Rabbit IgG 기반, Protein A 정제, 액상 형태. 세포 스트레스 반응 및 암 연구용으로 적합.
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Thermo Fisher Scientific p53 FL-393 Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:300 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:400 |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
| Flow Cytometry (Flow) | 1:20–1:100 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Full length human p53 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The tumor suppressor protein p53 is a sequence-specific transcription factor activated by cellular stress. It mediates cell cycle arrest or apoptosis in response to DNA damage or nucleotide starvation. p53 up-regulates genes such as p21waf1, contributing to G1 or G2/M arrest. Structurally, p53 includes:
- N-terminal transactivation domain
- Central DNA-binding domain
- Oligomerization domain
- C-terminal regulatory domain
Phosphorylation at Ser15 is crucial for activation and stabilization, while Ser392 phosphorylation is associated with tumor formation. p53 plays a key role in preventing proliferation of damaged cells, acting as an anticancer agent, and is linked to aging and oxidative stress. Mutations in TP53 lead to loss of tumor suppressor function and are found in many cancers, including hereditary cancer syndromes such as Li-Fraumeni.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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