Thermo Fisher Scientific SPTLC2 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1 µg/mL
• Publications: View 1 publication

Immunocytochemistry (ICC/IF)

• Tested Dilution: 10 µg/mL
• Publications: -

Product Specifications

Product Specific Information

• Suggested positive control: NIH-3T3 cell lysate
• PA5-21142 can be used with blocking peptide PEP-1256.

Target Information

Serine palmitoyltransferase (SPT), which consists of two different subunits, is the key enzyme in sphingolipid biosynthesis. It converts L-serine and palmitoyl-CoA to 3-oxosphinganine with pyridoxal 5'-phosphate as a cofactor.
SPT2 is the long chain base subunit 2 of mammalian serine palmitoyltransferase. SPT2 is catalytically active but requires its related protein SPT1 for stabilization and anchoring the holoenzyme to the cytosolic face of the endoplasmic reticulum.
Mutations in the SPT2 gene can cause hereditary sensory and autonomic neuropathy type I (HSAN-I), resulting from a loss of SPT activity and accumulation of the atypical neurotoxic sphingoid metabolite 1-deoxy-sphinganine.

For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.

제품 이미지

• PA5-21142_SPTLC2_O15270-1_Rabbit.svg
• PA5-21142_SPTLC2_O15270-1_Rabbit_PDP.jpeg