Thermo Fisher Scientific SPTLC2 Polyclonal Antibody
SPTLC2 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot 및 면역세포화학(ICC/IF)에 최적화. 항원 친화 크로마토그래피로 정제된 액상 형태. 인간 및 생쥐 시료에 반응하며 연구용으로 사용.
- 카탈로그번호
- PA521142
- 판매단위
- pk
카탈로그
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Applications
Western Blot (WB)
- Tested Dilution: 1 µg/mL
- Publications: View 1 publication
Immunocytochemistry (ICC/IF)
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A 15 amino acid peptide near the carboxy terminus of human SPT2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Maintain refrigerated at 2–8°C for up to 3 months. For long term storage store at -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11154528 |
Product Specific Information
- Suggested positive control: NIH-3T3 cell lysate
- PA5-21142 can be used with blocking peptide PEP-1256.
Target Information
Serine palmitoyltransferase (SPT), which consists of two different subunits, is the key enzyme in sphingolipid biosynthesis. It converts L-serine and palmitoyl-CoA to 3-oxosphinganine with pyridoxal 5'-phosphate as a cofactor.
SPT2 is the long chain base subunit 2 of mammalian serine palmitoyltransferase. SPT2 is catalytically active but requires its related protein SPT1 for stabilization and anchoring the holoenzyme to the cytosolic face of the endoplasmic reticulum.
Mutations in the SPT2 gene can cause hereditary sensory and autonomic neuropathy type I (HSAN-I), resulting from a loss of SPT activity and accumulation of the atypical neurotoxic sphingoid metabolite 1-deoxy-sphinganine.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
- PA5-21142_SPTLC2_O15270-1_Rabbit.svg
- PA5-21142_SPTLC2_O15270-1_Rabbit_PDP.jpeg
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