Thermo Fisher Scientific C4BPB Recombinant Rabbit Monoclonal Antibody (23GB3715)
Recombinant rabbit monoclonal antibody specific to human C4BPB. Validated for WB and ICC/IF applications. Produced in HEK293F cells and purified by affinity chromatography. Supplied in PBS with glycerol and sodium azide for stable storage at -20°C.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:5,000 |
| Immunocytochemistry (ICC/IF) | 1:1,000 |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293F |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 23GB3715 |
| Immunogen | A synthetic peptide of human C4 binding protein (1–252 AA) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice (domestic); Dry ice (international) |
Target Information
Complement component 4-binding protein (C4BP) is a plasma glycoprotein that inhibits the classical pathway of complement activation, which is mediated through antibody targeting of foreign antigens. Structurally, C4BP is a disulfide-linked, multimeric protein composed of seven alpha chains and one beta chain. C4BP functions as a cofactor for C3β inactivator in the cleavage of C3β and accelerates the decay of C4βC2α (C3 convertase) by acting as a cofactor in the cleavage of C4β by factor I. Streptococcal strains expressing Ig-binding surface molecules (M protein family) can bind to overlapping C4β binding sites in C4BP, interfering with the classical complement pathway. Bacteria-bound C4BP may help downregulate complement activation, reducing bacterial opsonization and phagocytosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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배송 정보
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