Thermo Fisher Scientific T4S20 Polyclonal Antibody
Thermo Fisher Scientific의 T4S20 폴리클로날 항체는 인간 단백질에 특이적으로 반응하며 Western blot에 적합합니다. 친화 크로마토그래피로 정제된 액상 형태로 제공되며, 안정적인 PBS 버퍼에 보관됩니다. 연구용으로만 사용 가능합니다.
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Applications
Western Blot (WB)
- Tested Dilution: 0.2–1.0 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide directed towards the middle region of human T4S20 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 2% sucrose |
| Contains | 0.09% sodium azide |
| Storage Conditions | −20 °C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2688877 |
Product Specific Information
This target displays homology in the following species:
- Dog: 77%
- Human: 100%
- Rabbit: 83%
- Rat: 83%
Target Information
Polytopic transmembrane protein that inhibits regulated intramembrane proteolysis (RIP) of CREB3L1, inhibiting its activation and the induction of collagen synthesis (PubMed:25310401, PubMed:27499293).
In response to ceramide, which alters TM4SF20 membrane topology, it stimulates RIP activation of CREB3L1 (PubMed:27499293).
Ceramide reverses the direction through which transmembrane helices are translocated into the endoplasmic reticulum membrane during translation of TM4SF20. This mechanism, called regulated alternative translocation (RAT), regulates the function of the transmembrane protein (PubMed:27499293).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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