Thermo Fisher Scientific PLSCR1 Polyclonal Antibody
Thermo Fisher Scientific의 PLSCR1 폴리클로날 항체로, Western blot, IHC, ICC/IF에 사용 가능. Human 시료에 반응하며, 항원 친화 크로마토그래피로 정제됨. 단기 4℃, 장기 -20℃ 보관 권장. 연구용으로만 사용.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:100–1:1,000 |
Product Specifications
| Specification | Detail |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fragment corresponding to a region within amino acids 1–286 of Scramblase1 (Uniprot ID: O15162) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.52 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | 0.1M Tris glycine, pH 7, with 10% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_11153452 |
Product Specific Information
- Recommended positive controls: 293T, A431, H1299, HeLaS3, HepG2, Molt-4
- Predicted reactivity: Rhesus Monkey (96%)
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
The calcium-dependent plasma membrane protein phospholipid scramblase 1 (PLSCR1) contributes to the transbilayer movement of phosphatidylserine and other membrane phospholipids upon calcium influx into the cytosol. This movement leads to plasma membrane phospholipid remodeling and surface exposure of phosphatidylserine in injured or apoptotic cells, resulting in cell death. Interferons and other cytokines induce expression of PLSCR1, indicating its role in cytokine signaling pathways. EGF stimulation results in tyrosine phosphorylation of PLSCR1 at tyrosines 69 and 74, enabling interaction with Shc and linking Src kinase activation to EGF receptor stimulation.
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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