Thermo Fisher Scientific ATM Polyclonal Antibody, Biotin
ATM 단백질을 인식하는 Biotin 결합 폴리클로날 항체로, Western blot, IHC, ICC/IF, Flow cytometry, ELISA 등 다양한 응용에 사용 가능. Rabbit IgG 유래로 항원 친화 크로마토그래피로 정제됨. 4°C 암소 보관, 연구용 전용.
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Applications and Tested Dilution
| Application | Tested Dilution | Notes |
|---|---|---|
| Western Blot (WB) | 1:500–1:1,000 | |
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent | |
| Immunocytochemistry (ICC/IF) | 1:100 | |
| Flow Cytometry (Flow) | Assay-dependent | |
| ELISA | Assay-dependent |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Dog, Human, Marsupial, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A fragment of human ATM protein expressed in E. coli, corresponding to the C-terminal region (within the last third of the protein sequence). |
| Conjugate | Biotin |
| Form | Liquid |
| Concentration | 1.51 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C, store in dark |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11154169 |
Target Information
Ataxia-telangiectasia Mutated (ATM) belongs to the PI3/PI4 kinase family. Ataxia-telangiectasia is a rare autosomal recessive disorder characterized by progressive neurologic degeneration, immunologic deficiency, and increased risk of lymphoid cancer. The ATM gene encodes a protein of the phosphoinositide 3-kinase (PI3K) superfamily, which phosphorylates proteins involved in cell-cycle regulation such as P53, Mdm2, BRCA1, and SMC1.
ATM is crucial for repairing double-stranded DNA breaks caused by ionizing radiation and other mutagens. The C-terminal region of ATM shows homology to catalytic domains of PI3 kinases. Upon exposure to ionizing radiation, ATM becomes autophosphorylated and activated, initiating kinase cascades that regulate cell cycle, apoptosis, and DNA damage repair.
ATM also interacts with Nbs1 and Chk2 in the E2F1 pathway, linking it to apoptosis regulation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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