Thermo Fisher Scientific NCF2 Polyclonal Antibody
Thermo Fisher Scientific의 NCF2 Polyclonal Antibody는 인간과 생쥐 시료에 반응하는 rabbit IgG 항체로, WB, IHC, ELISA에 사용 가능. 고순도 Affinity Chromatography 정제, -20°C 보관, 세포질 내 NCF2 단백질 검출에 적합.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 227–526 of human NOXA2/p67phox (NP_0004242) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 7.65 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2804778 |
Product Specific Information
- Immunogen sequence:
PPPRPKTPEI FRALEGEAHR VLFGFVPETK EELQVMPGNI VFVLKKGNDN WATVMFNGQK GLVPCNYLEP VELRIHPQQQ PQEESSPQSD IPAPPSSKAP GRPQLSPGQK QKEEPKEVKL SVPMPYTLKV HYKYTVVMKT QPGLPYSQVR DMVSKKLELR LEHTKLSYRP RDSNELVPLS EDSMKDAWGQ VKNYCLTLWC ENTVGDQGFP DEPKESEKAD ANNQTTEPQL KKGSQVEALF SYEATQPEDL EFQEGDIILV LSKVNEEWLE GECKGKVGIF PKVFVEDCAT TDLESTRREV - Positive Samples: THP-1, Mouse spleen
- Cellular Location: Cytoplasm
Target Information
NCF2, NCF1, and a membrane-bound cytochrome b558 are required for activation of the latent NADPH oxidase, necessary for superoxide production.
Defects in NCF2 cause chronic granulomatous disease autosomal recessive cytochrome-b-positive type 2 (CGD2).
This disease is characterized by the inability of neutrophils and phagocytes to kill ingested microbes, leading to life-threatening bacterial and fungal infections.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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