StirCradle-Pro

견적요청
제품상담 버튼을 클릭하시면 해당 제품에 대해 문의하실 수 있습니다.
판매자: 비티알
브랜드: Esco

StirCradle-Pro

The StirCradle-Pro is a fully stainless steel fermenter/bioreactor system designed with an automated 5-step cycle SIP system for both culture medium and reactor vessel. VacciXcell offers a wide range of standard reactor capacities from 20L up to 1000L' however, customized reactor sizes are available should the users require.

StirCradle-Pro features various advanced design and assembly to facilitate the fermentation/culture process including reactor design that eliminates blind spots and increases oxygen retention rate, lifting system for easy cleaning of reactor vessel, and LED light for easy viewing within the culture tank.

VacciXcell simplifies scale up from the laboratory to pilot and production scale by providing analysis data as reference for scale-up conditions. Apart from customized sizes, VacciXcell also offers parametric programming and special vessel development to help speed up the experiment. Vaccixcell offers complete documentation of system parts.

Smart Control System
  • Uses SCADA system
  • 15” Touch Screen Colored HMI with real-time 3D view of the fermentation/culture process and user-friendly display
  • Real-time culture trend chart data logging. Internal continuous recording storage:
    • Up to 12.5 days: 1 data every 30seconds
    • Up to 25 days: 1 data every minute
    • Up to 50 days: 1 data every 2 minutes
  • Quick download via USB in .xls format
  • Optional documentation for 21 CFR Part 11 compliance
  • Remote sharing via ethernet port or wireless sharing device
Enhanced Design of Reactor Vessel and Components
  • Above 70% working volume, tank designed to eliminate blind spots
  • LED light for easy viewing inside the tank
  • Multiple options for inoculation:
    • Quick Release Enhanced Short-Necked Dosing Port
    • Combustion Implant Bacteria Port
    • Diaphragm needle injection
  • Φ25 Standard Configurable Electrode Ports for pH and DO
  • All the contact surfaces inside the tank are polished by mechanical MP#400+EP and outside the tank by mechanical MP#300+EP
  • Shell and Tube Condenser:
    • Inside Material: SUS316
    • Outside Piping: SUS304
    • Sanitary Quick Disassembly to Facilitate Cleaning
  • Safe design of pipings allow simple disassembly and replacement without affecting the process
  • Impellers are designed to achieve high bubbles dispersion rate efficiency and kLa value
  • Sanitary Clamp Joint Clips Applied to Pressure Sensor, Diaphragm Type Manometer Port, and Prepare Feed Port.
Built-in Configurable Pumps
  • Four (4) built-in configurable peristaltic pumps for fluid addition
  • Each pump can be set as either Alkali, Acid, Feed or Antifoam
  • Pump can be calibrated and flow can be set using speed%
Sterilization-in-Place (SIP)
  • Automated SIP system for both reactor vessel and culture medium
  • SIP program features 5 steps: Heating 1, Heating 2, Sterilization, Cooling 1, and Cooling 2
  • Optional Cleaning-in-Place (CIP) system
Validation and Documentation

VacciXcell provides a thorough validation and documentation package for StirCradle™-Pro

  • Validation Packages is inclusive of the following:

    • Material Certificate

    • Production Control Table

    • Welding Record

    • Pressure Testing Report

    • Operation Manual

    • Equipment Outline Chart

    • P&ID Chart

    • Electrical Loop Chart

    • Ra Testing Report

  • Optional IQ/OQ/PQ documentation

Other Features
  • Automated Sterilization-In-Place (SIP)

  • Batch, fed-batch, continuously-batch, semi-continuous and high-density batch systems

  • Enhanced High Resistance Torque Bearing Transmission Unit and Transmission Bracket (SUS304+ Surface EP Processing).

  • Online Repeatable Sterilization Dry-Type Cartridge Pattern Mechanical Shaft Seal.

  • Sterilizable Quick Release Air Pipe (Anti-Clogging Highly Dispersed Air Sparger ), can be easily removed and cleaned.

  • High Sensitivity Speed Sensor (1,000Hz) using PID Automatic Calculation Feedback Compensated Output to Stepless Speed Change Inverter (Can Control Rotational Speed at ±1rpm ).

  • Cooling Water Y Type Filter, Steam Filter, Steam Pressure Reducing Valve, Air Duplex Preliminary Filtrate Group and Air Pressure Reducing Valve Group.

  • Pipe control unit:

    • Sterilization control valve
    • Temperature control piping manifolds
    • Sterile ventilation control piping manifolds
    • Exhaust tank pressure piping manifolds dosing the fed control valve (of four groups /sets)
    • Transfer transmission inoculation control manifolds pipeline.
  • In case of power outage, positive pressure is kept in the vessel for more than 24 hours. Parameters can be controlled

  • Pilot and production scale of fermentation processes of microorganisms such as yeast, bacteria, and fungi

  • Pilot and production scale of cells such as insect cells and suspended mammalian cells

  • Pilot and production scale of the manufacturing of biopharmaceuticals such as recombinant proteins, vaccines, and monoclobal antibodies

Sterilization in Place (SIP) Screen

Fig1. - Sterilization in Place (SIP) Screen

  • SIP screen shows real-time view of sterilization process:

    • Shows the current step of the sterilization process
    • Shows open or close valves
    • Shows the present and set values for sterilization parameters: temperature, agitation, air, pressure, and time
  • 5-step sterilization process:

    • Heating 1 – 100% steam in heating jacket

    • Heating 2 – Steam in heating jacket and Air filter

    • Cooling 1 – Use of air for cool down system to 50 – 60oC

    • Cooling 2 – Use of chilled water/tap water to completely cool down system

  • Sterilization modules for both reactor vessel culture medium

Culture Screen

Fig1. - Culture Screen

  • Real-time dynamic display of culture process
  • Shows the set value and present value of all parameters, open and closed valves, and total volume of liquid added by each pump
  • Users can switch between automatic and manual control of parameters
  • Shows the total culture time
Feed Setting Screen

Fig1. - Feed Setting Screen

  • Users can set the flow rates for each pump. Once flow rate for each pump is set, flow of each pump can be controlled via speed percentage.
  • Users can set the pump as one of the following:
    • On/Off: Users control pumping without depending on parameter values
    • DO Stat: Pumping is controlled by changes in DO value, depending on the criteria set by the user
    • pH Stat Pumping is controlled by changes in pH value, depending on the criteria set by the user
Step Control Setting Screen

Fig1. - Step Control Setting Screen

  • Users can set a 50-step control program for temperature, agitation, pH, DO, aeration, and feeding
  • Up to 20 step programs can be saved for each parameter. Saved programs can be loaded, modified and deleted.
  • Users can select the point on a step program at which the program will begin
  • The 50-step parameter control is designed to ease and automate user control of the culture/fermentation process
Sterilization and Culture Setting Screen

Fig1. - Sterilization and Culture Setting Screen

  • Users can set the parameter values for the sterilization cycle and culture process
  • For sterilization process, users set the end temperatures for each sterilization step, agitation speed, pressure, airflow, and total time of sterilization.
  • For culture settings, users can choose to have automatic or step control of the parameters:
    • Automatic: controlled by the set value (SV) of the user
    • Step: controlled by the step setting of the user
  • Users can set one of the following DO control modes they require:
    • Agitation speed
    • Vent Control
    • Agitation speed -> Air -> O2
    • Vent -> Agitation speed -> O2
  • Users can designate one of the following settings for the peristaltic pumps:
    • None: no pump action
    • Acid: acid addition
    • Alkl: alkali addition
    • AF: antifoam addition
    • Feed: feed addition
  • Foaming can be controlled using one of the two options:
    • Antifoam –addition of antifoam
    • Defoam – use of pressure
Features Unit StirCradle-Pro 20 StirCradle-Pro 30 StirCradle-Pro 50 StirCradle-Pro 100 StirCradle-Pro 200 StirCradle-Pro 500 StirCradle-Pro 1000
Nominal Volume l 20 30 50 100 200 500 1000
Total Volume l 25 34 56 126 220 620 1120
Working Volume l 15 20 35 75 150 400 750
Tank Inner Diameter (D) mm 260 260 310 400 480 680 830
Tank Depth mm 450 620 730 980 1200 1650 2000
Mixing Blade Diamater NA D/3 D/2.5 D/3 D/2.5 D/3 D/2.5 D/3 D/2.5 D/3 D/2.5 D/3 D/2.5 D/3
mm 87 104 87 104 103 124 133 160 160 192 227 272 277 332
Agitation Speed rpm 80 - 1000 80 - 1000 80 - 800 60 - 600 60 - 600 60 - 550 40 - 400
Precision rpm +/-1rpm
Blade tip maximum speed m/s 3.6 4.4 3.6 4.4 4.4 5.2 4.2 5 5 5 5.9 5.7 5.8
pH Range NA 0-14
Precision NA +/-0.01
Temperature Precision oC +/-0.01oC
Heating NA Hot water tank
Cooling NA Tap or Chilled water tank
Dissolved Oxygen Range % 0-200%
Precision % Display: +/-0.1% Control: +/-0.2=0.5%
Noise Level dB <100 dB
Pumps NA 4 built-in configurage pumps (up to 3 additional external pumps)
Airflow
Air flow (0.3kg/ cm2 cultre) vvm 2.3 2.3 2 2 2.1 2 2.2
Total electricity demand 220V/3 A 7 8 10 20 35 60 100
Steam demand (2kg/ cm2 G 133 oC) kg/hr 15 20 30 60 130 250 300
Air Demand(2kg/ cm²G) 1/min 36 48 75 159 333 848 36
Cooling Water Demand(2kg/ cm²G 20°C) m³/hr 0.3 0.4 0.5 0.8 1.5 2.5 4
Continue Caliber Steam A 8 10 10 15 25 25 25
Air A 8 10 10 15 20 25 40
Water A 8 10 10 15 20 25 25
Dosing Equipment speed adjustable ??peristaltic pump×3 10L dosing tankx3
Optional Feeding Equipment speed adjustable ??peristaltic pump×1 20L feed tankx1
Dosing Bottle Sterilization Autoclave Online resterilization
Fermenter Sterilization automatic or manual in place
Others automatic tank cover lifting with operator frame Attached control console

Features

Smart Control System
  • Uses SCADA system
  • 15” Touch Screen Colored HMI with real-time 3D view of the fermentation/culture process and user-friendly display
  • Real-time culture trend chart data logging. Internal continuous recording storage:
    • Up to 12.5 days: 1 data every 30seconds
    • Up to 25 days: 1 data every minute
    • Up to 50 days: 1 data every 2 minutes
  • Quick download via USB in .xls format
  • Optional documentation for 21 CFR Part 11 compliance
  • Remote sharing via ethernet port or wireless sharing device
Enhanced Design of Reactor Vessel and Components
  • Above 70% working volume, tank designed to eliminate blind spots
  • LED light for easy viewing inside the tank
  • Multiple options for inoculation:
    • Quick Release Enhanced Short-Necked Dosing Port
    • Combustion Implant Bacteria Port
    • Diaphragm needle injection
  • Φ25 Standard Configurable Electrode Ports for pH and DO
  • All the contact surfaces inside the tank are polished by mechanical MP#400+EP and outside the tank by mechanical MP#300+EP
  • Shell and Tube Condenser:
    • Inside Material: SUS316
    • Outside Piping: SUS304
    • Sanitary Quick Disassembly to Facilitate Cleaning
  • Safe design of pipings allow simple disassembly and replacement without affecting the process
  • Impellers are designed to achieve high bubbles dispersion rate efficiency and kLa value
  • Sanitary Clamp Joint Clips Applied to Pressure Sensor, Diaphragm Type Manometer Port, and Prepare Feed Port.
Built-in Configurable Pumps
  • Four (4) built-in configurable peristaltic pumps for fluid addition
  • Each pump can be set as either Alkali, Acid, Feed or Antifoam
  • Pump can be calibrated and flow can be set using speed%
Sterilization-in-Place (SIP)
  • Automated SIP system for both reactor vessel and culture medium
  • SIP program features 5 steps: Heating 1, Heating 2, Sterilization, Cooling 1, and Cooling 2
  • Optional Cleaning-in-Place (CIP) system
Validation and Documentation

VacciXcell provides a thorough validation and documentation package for StirCradle™-Pro

  • Validation Packages is inclusive of the following:

    • Material Certificate

    • Production Control Table

    • Welding Record

    • Pressure Testing Report

    • Operation Manual

    • Equipment Outline Chart

    • P&ID Chart

    • Electrical Loop Chart

    • Ra Testing Report

  • Optional IQ/OQ/PQ documentation

Other Features
  • Automated Sterilization-In-Place (SIP)
  • Batch, fed-batch, continuously-batch, semi-continuous and high-density batch systems
  • Enhanced High Resistance Torque Bearing Transmission Unit and Transmission Bracket (SUS304+ Surface EP Processing).
  • Online Repeatable Sterilization Dry-Type Cartridge Pattern Mechanical Shaft Seal.
  • Sterilizable Quick Release Air Pipe (Anti-Clogging Highly Dispersed Air Sparger ), can be easily removed and cleaned.
  • High Sensitivity Speed Sensor (1,000Hz) using PID Automatic Calculation Feedback Compensated Output to Stepless Speed Change Inverter (Can Control Rotational Speed at ±1rpm ).
  • Cooling Water Y Type Filter, Steam Filter, Steam Pressure Reducing Valve, Air Duplex Preliminary Filtrate Group and Air Pressure Reducing Valve Group.
  • Pipe control unit:
    • Sterilization control valve
    • Temperature control piping manifolds
    • Sterile ventilation control piping manifolds
    • Exhaust tank pressure piping manifolds dosing the fed control valve (of four groups /sets)
    • Transfer transmission inoculation control manifolds pipeline.
  • In case of power outage, positive pressure is kept in the vessel for more than 24 hours. Parameters can be controlled

Applications

  • Pilot and production scale of fermentation processes of microorganisms such as yeast, bacteria, and fungi
  • Pilot and production scale of cells such as insect cells and suspended mammalian cells
  • Pilot and production scale of the manufacturing of biopharmaceuticals such as recombinant proteins, vaccines, and monoclobal antibodies

Interface

Sterilization in Place (SIP) Screen

Fig1. - Sterilization in Place (SIP) Screen

  • SIP screen shows real-time view of sterilization process:

    • Shows the current step of the sterilization process
    • Shows open or close valves
    • Shows the present and set values for sterilization parameters: temperature, agitation, air, pressure, and time
  • 5-step sterilization process:

    • Heating 1 – 100% steam in heating jacket

    • Heating 2 – Steam in heating jacket and Air filter

    • Cooling 1 – Use of air for cool down system to 50 – 60oC

    • Cooling 2 – Use of chilled water/tap water to completely cool down system

  • Sterilization modules for both reactor vessel culture medium

Culture Screen

Fig1. - Culture Screen

  • Real-time dynamic display of culture process
  • Shows the set value and present value of all parameters, open and closed valves, and total volume of liquid added by each pump
  • Users can switch between automatic and manual control of parameters
  • Shows the total culture time
Feed Setting Screen

Fig1. - Feed Setting Screen

  • Users can set the flow rates for each pump. Once flow rate for each pump is set, flow of each pump can be controlled via speed percentage.
  • Users can set the pump as one of the following:
    • On/Off: Users control pumping without depending on parameter values
    • DO Stat: Pumping is controlled by changes in DO value, depending on the criteria set by the user
    • pH Stat Pumping is controlled by changes in pH value, depending on the criteria set by the user
Step Control Setting Screen

Fig1. - Step Control Setting Screen

  • Users can set a 50-step control program for temperature, agitation, pH, DO, aeration, and feeding
  • Up to 20 step programs can be saved for each parameter. Saved programs can be loaded, modified and deleted.
  • Users can select the point on a step program at which the program will begin
  • The 50-step parameter control is designed to ease and automate user control of the culture/fermentation process
Sterilization and Culture Setting Screen

Fig1. - Sterilization and Culture Setting Screen

  • Users can set the parameter values for the sterilization cycle and culture process
  • For sterilization process, users set the end temperatures for each sterilization step, agitation speed, pressure, airflow, and total time of sterilization.
  • For culture settings, users can choose to have automatic or step control of the parameters:
    • Automatic: controlled by the set value (SV) of the user
    • Step: controlled by the step setting of the user
  • Users can set one of the following DO control modes they require:
    • Agitation speed
    • Vent Control
    • Agitation speed -> Air -> O2
    • Vent -> Agitation speed -> O2
  • Users can designate one of the following settings for the peristaltic pumps:
    • None: no pump action
    • Acid: acid addition
    • Alkl: alkali addition
    • AF: antifoam addition
    • Feed: feed addition
  • Foaming can be controlled using one of the two options:
    • Antifoam –addition of antifoam
    • Defoam – use of pressure

Models

Features Unit StirCradle-Pro 20 StirCradle-Pro 30 StirCradle-Pro 50 StirCradle-Pro 100 StirCradle-Pro 200 StirCradle-Pro 500 StirCradle-Pro 1000
Nominal Volume l 20 30 50 100 200 500 1000
Total Volume l 25 34 56 126 220 620 1120
Working Volume l 15 20 35 75 150 400 750
Tank Inner Diameter (D) mm 260 260 310 400 480 680 830
Tank Depth mm 450 620 730 980 1200 1650 2000
Mixing Blade Diamater NA D/3 D/2.5 D/3 D/2.5 D/3 D/2.5 D/3 D/2.5 D/3 D/2.5 D/3 D/2.5 D/3
mm 87 104 87 104 103 124 133 160 160 192 227 272 277 332
Agitation Speed rpm 80 - 1000 80 - 1000 80 - 800 60 - 600 60 - 600 60 - 550 40 - 400
Precision rpm +/-1rpm
Blade tip maximum speed m/s 3.6 4.4 3.6 4.4 4.4 5.2 4.2 5 5 5 5.9 5.7 5.8
pH Range NA 0-14
Precision NA +/-0.01
Temperature Precision oC +/-0.01oC
Heating NA Hot water tank
Cooling NA Tap or Chilled water tank
Dissolved Oxygen Range % 0-200%
Precision % Display: +/-0.1% Control: +/-0.2=0.5%
Noise Level dB <100 dB
Pumps NA 4 built-in configurage pumps (up to 3 additional external pumps)
Airflow
Air flow (0.3kg/ cm2 cultre) vvm 2.3 2.3 2 2 2.1 2 2.2
Total electricity demand 220V/3 A 7 8 10 20 35 60 100
Steam demand (2kg/ cm2 G 133 oC) kg/hr 15 20 30 60 130 250 300
Air Demand(2kg/ cm²G) 1/min 36 48 75 159 333 848 36
Cooling Water Demand(2kg/ cm²G 20°C) m³/hr 0.3 0.4 0.5 0.8 1.5 2.5 4
Continue Caliber Steam A 8 10 10 15 25 25 25
Air A 8 10 10 15 20 25 40
Water A 8 10 10 15 20 25 25
Dosing Equipment speed adjustable ??peristaltic pump×3 10L dosing tankx3
Optional Feeding Equipment speed adjustable ??peristaltic pump×1 20L feed tankx1
Dosing Bottle Sterilization Autoclave Online resterilization
Fermenter Sterilization automatic or manual in place
Others automatic tank cover lifting with operator frame Attached control console

배송/결제/교환/반품 안내

배송 정보

기본 배송비
  • - 3,000원 (배송비 3,000원 + 부가세 300원)
  • - 10만원 이상 구매시 배송비 무료
  • - 도서산간 및 제주를 포함한 일부 지역 추가비용 발생
교환/반품 배송비
  • - 상품 별로 상이
착불 배송비
  • - 착불 적용 상품에 개별 부과 (상품 별로 상이)
  • - 착불 상품의 경우 판매처마다 배송을 할 수 있기 때문에 중복으로 착불비가 발생 가능
  • - 일반 상품과 함께 구매하더라도 해당 판매업체의 구매 금액에 따라 착불 배송비 발생 가능
교환/반품 배송비
  • - 상품 별로 상이

결제 및 환불 안내

결제 방법
  • - 신용카드
  • - 실시간 계좌이체
취소
  • - 취소 접수 후 3 ~ 5일 이내 환불 처리
반품
  • - 반품 접수 후 3 ~ 5일 이내 환불 처리

교환 및 반품 접수

교환 및 반품 접수 기한
  • - 상품 수령일로부터 7일 이내
교환 및 반품 접수가 가능한 경우
  • - 제품의 하자는 없지만, 다른 상품으로 교환하거나 반품 원하는 경우
     (배송비 고객 부담)
  • - 상품자체 불량 및 하자에 의한 경우
  • - 상품 오배송에 의한 경우
교환 및 반품 접수가 불가능한 경우
  • - 상품 수령 후 7일을 초과한 경우
  • - 개별 포장 상품의 포장을 훼손한 경우
  • - 고객의 고의적인 귀책으로 상품가치가 훼손된 경우
  • - 주문제작을 통해서 제품을 생산하는 경우
  • - 주문 당시 재고가 없어서 해외를 통해 제품을 수입해서 구매하는 경우

교환 및 반품 신청

교환 절차
  • - 상품 불량/오배송/상품파손
  • - 전화(02-585-1342) 또는 info@cacheby.com에 상품교환 접수
반품 절차
  • - 반품할 품목을 확인 후 info@cacheby.com로 반품 신청 (수령 후 7일 이내 가능하며 이후 불가)
  • - 전달드린 주문번호와 함께 반품 상품을 포장
     (포장을 꼼꼼하게 해주셔야 반품 상품 손상에 따른 불이익이 없습니다.)
  • - 택배회사 방문 시 반품 상품 전달
     (택배사의 반송장은 상품 교환이 완료될 때까지 보관해주시기 바랍니다.)

상품문의 0

비티알의 다른 상품들

thumbnail

VacciXcell offers a stand-alone capping machine, as the application of aluminium caps is a ‘dirty’ process, wherein many particulates are created. However, an integrated filling/stoppering/capping monoblock is feasible should the customer require it....

thumbnail

The Isoclean® Platform Isolator facilitates the isolation of a product or process while providing the required for sterile/aseptic environment. It is configured to operate at positive or negative pressure. This equipment provides a comprehensive rang...

thumbnail

Incorporating all the latest design features available on Esco's NSF-listed Labculture Class II Type A2 biosafety cabinet, Esco Labculture Class II Type B2 biosafety cabinets are designed to provide operator, products and environmental protection in ...

thumbnail

Crystal Violet Dye Nuclei Count Kit is a simple tool for the quantification of cells based on the number of nuclei dyed. The CVD kit contains reagents that disrupt the cells, ...

thumbnail

The StirCradle-Pro is a fully stainless steel fermenter/bioreactor system designed with an automated 5-step cycle SIP system for both culture medium and reactor vessel. VacciXcell offers a wide range of standard reactor capacities from 20L up to 1000...